Apr 28, 2023Liked by Packy McCormick, Daniel McCormick
The brain imaging thing is awesome - make sure you don’t miss this potential breakthrough where they’re potentially delivering drugs to stop neurodegenerative diseases right past the brain-blood barrier. They’re using ultrasound pulses to do it and it looks promising so far!
Congratulations! We share a love of the Philadelphia Eagles (I live in South Philly), a last name (supposedly from County Mayo generations ago), and a sense of awe regarding the MRI progress.
That insane degree of resolution might reveal new clues to the structures of things like plaques and tangles in Alzheimer’s - but these degenerative diseases are so multifactorial that such heightened imaging sensitivity will likely not crack any codes by itself. Another piece of the puzzle, and like the Hubble and now JWST, simply observing the world at unfathomable resolutions often helps science find the unexpected, and provides a sense of awe and humility for those of us watching the show.
That Sprig integration has me intrigued. I wonder how long it will take Substack to start partnering with 3rd party apps for services like that. I'd love to see a loyalty incentives integration.
Yes, I just hijacked the thread, but I'm guessing some others feel the same. Thanks for the post, Packy.
There is a lot of talk about "reshoring" or at least partial reshoring. Even with automation, from what I have read, these facilities will cost more to operate. It is one reason I think that the goal of 2 percent annual inflation is not going to happen anytime soon, maybe 3 percent will be the new floor.
This is not a problem, of course, if we maintain employment and wage growth, but that remains to be seen.
The growth that Packy has done is incredible! Would love to replicate that, even though 200,000 words a week seems daunting...
The brain imaging thing is awesome - make sure you don’t miss this potential breakthrough where they’re potentially delivering drugs to stop neurodegenerative diseases right past the brain-blood barrier. They’re using ultrasound pulses to do it and it looks promising so far!
https://medicalxpress.com/news/2023-04-blood-brain-barrier-usher-age-gene.html
200k is an impressive milestone! Way to go!
Also, keep going with the Weekly Dose of Optimism. I look forward to reading as much as your in-depth pieces.
Congratulations! We share a love of the Philadelphia Eagles (I live in South Philly), a last name (supposedly from County Mayo generations ago), and a sense of awe regarding the MRI progress.
That insane degree of resolution might reveal new clues to the structures of things like plaques and tangles in Alzheimer’s - but these degenerative diseases are so multifactorial that such heightened imaging sensitivity will likely not crack any codes by itself. Another piece of the puzzle, and like the Hubble and now JWST, simply observing the world at unfathomable resolutions often helps science find the unexpected, and provides a sense of awe and humility for those of us watching the show.
The data about the emotional load behind headlines is simply mind blowing!
That Sprig integration has me intrigued. I wonder how long it will take Substack to start partnering with 3rd party apps for services like that. I'd love to see a loyalty incentives integration.
Yes, I just hijacked the thread, but I'm guessing some others feel the same. Thanks for the post, Packy.
There is a lot of talk about "reshoring" or at least partial reshoring. Even with automation, from what I have read, these facilities will cost more to operate. It is one reason I think that the goal of 2 percent annual inflation is not going to happen anytime soon, maybe 3 percent will be the new floor.
This is not a problem, of course, if we maintain employment and wage growth, but that remains to be seen.
Thanks, Packy, for all your tech updates!
Congrats on 200k! Thanks for surfacing the optimistic news of today in service of a brighter tomorrow.
re: Cruise
It isn't a random event why Cruise taxis are only available to non-Cruise users until after 10 pm.
Cruise vehicles have, just in the past 2 months:
1) Blocked a road
2) Hit a City of SF bus
Expanding into a year past - there were more blockages including due to a crashed server.
Given that traffic has returned to SF as evidenced by RSA - this grand release ought to be interesting.